| 摘要 |
<p>The present invention relates to a peptide comprising or consisting of a sequence of formula (I) A-B-C-D-E-F (formula I), wherein A is a peptide consisting of three hydrophobic amino acid residues; B is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; C is a peptide consisting of two hydrophobic amino acid residues; D is a peptide consisting of two basic amino acid residues; E is a peptide consisting of two hydrophobic amino acid residues; and F is a peptide consisting of two basic amino acid residues; or a peptidomimetic thereof; wherein the basic amino acid residues are selected from the group consisting of arginine, lysine and histidine; wherein the hydrophobic amino acid residues are selected from the group consisting of leucine, alanine, valine, isoleucine, methionine and phenylalanine; and wherein said peptide or peptidomimetic has antimicrobial activity. Furthermore, the invention relates to a nucleic acid molecule encoding the peptide of the invention, a vector comprising the nucleic acid molecule as well as a host cell comprising the nucleic acid molecule or the vector. The present invention also relates to a method for producing the peptide of the invention, a composition as well as to the peptide of the invention for use in treating infectious diseases.</p> |
