PROCESS FOR THE PREPARATION OF VINPOCETINE AND APOVINCAMINE

摘要

A process for the preparation of vinpocetine and apovincamine, wherein said process comprises the steps of: (1 ) preparing a solution of the compound of formula (II) below and an organic or inorganic base in a polar aprotic solvent, and (2) adding an alkyl haloacetate to the solution of step (1 ) under controlled temperature conditions.