发明名称 |
QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS |
摘要 |
<p>Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.</p> |
申请公布号 |
CA2738809(A1) |
申请公布日期 |
2010.04.01 |
申请号 |
CA20092738809 |
申请日期 |
2009.09.29 |
申请人 |
SIRTRIS PHARMACEUTICALS, INC. |
发明人 |
VU, CHI B.;OALMANN, CHRISTOPHER;PERNI, ROBERT B.;WHITE, BRIAN |
分类号 |
C07D401/12;A61K31/4375;A61K31/439;A61K31/4709;A61K31/497;A61K31/506;A61K31/517;A61K31/5377;A61P3/10;A61P5/50;C07D239/91;C07D401/14;C07D403/12;C07D403/14;C07D405/12;C07D413/12;C07D417/12;C07D417/14;C07D453/02 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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