发明名称 |
ANTIBODIES AGAINST HUMAN IL17 AND USES THEREOF |
摘要 |
<p>An antibody binding to IL- 17 characterized by binding to the same IL- 17 epitope to which monoclonal antibody 3C1 binds, and being of human IgG1 isotype modified in the hinge region at amino acid position 216-240, preferably at amino acid position 220-240, between CH1 and CH2 and/or in the second inter-domain region at amino acid position 327-331 between CH2 and CH3 has advantageous properties for the treatment of inflammatory diseases.</p> |
申请公布号 |
CA2737636(A1) |
申请公布日期 |
2010.04.01 |
申请号 |
CA20092737636 |
申请日期 |
2009.09.21 |
申请人 |
ROCHE GLYCART AG |
发明人 |
AUER, JOHANNES;DIMOUDIS, NIKOLAOS;GEORGES, GUY;HANKE, PETRA;KNOETGEN, HENDRIK;LANGRISH, CLAIRE LOUISE;MOESSNER, EKKEHARD |
分类号 |
C07K16/24 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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