发明名称 |
MORPHOLINE DERIVATIVES AS RENIN INHIBITORS |
摘要 |
The present invention provides a morpholine derivative of the formula [I];
wherein R 1 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, a cycloalkyl group or an alkyl group; R 2 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, an optionally substituted alkylcarbonyl group, an optionally substituted arylcarbonyl group, an optionally substituted heterocyclo-substituted carbonyl group or a cycloalkylcarbonyl group; T is a methylene group or a carbonyl group; R 3 , R 4 , R 5 and R 6 are the same or different and a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group;
or pharmaceutically acceptable salts thereof. These compounds are useful as a renin inhibitor. |
申请公布号 |
EP2168952(A1) |
申请公布日期 |
2010.03.31 |
申请号 |
EP20080777242 |
申请日期 |
2008.06.16 |
申请人 |
MITSUBISHI TANABE PHARMA CORPORATION;SHANGHAI PHARMACEUTICAL (GROUP) CO., LTD. |
发明人 |
AKATSUKA, HIDENORI;SUGAMA, HIROSHI;AWAI, NOBUMASA;KAWAGUCHI, TAKAYUKI;TAKAHASHI, YOICHI;IIJIMA, TORU;SHEN, JINGKANG;XIA, GUANGXIN;XIE, JIANSHU |
分类号 |
C07D265/30;A61K31/5375;A61K31/538;A61P9/04;A61P9/12;A61P13/12;A61P43/00;C07D265/36;C07D413/12 |
主分类号 |
C07D265/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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