发明名称 |
SIGNAL SEQUENCES FOR THE PRODUCTION OF LEU−HIRUDINE VIA SECRETION BY E. COLI |
摘要 |
The present invention relates to a efficient expression of a protein, particularly, hirudin; a protein precursor comprising a signal sequence and the sequence of aa<SUB>X</SUB>-hirudin, wherein aa<SUB>X </SUB>is a selected amino acid, and aa<SUB>X </SUB>is preferably leucine; to its preparation and use; and to processes for finding signal sequences for secretory expression of any desired protein in E coli; and to processes for the secretory expression of any desired protein in E coli. |
申请公布号 |
PL205117(B1) |
申请公布日期 |
2010.03.31 |
申请号 |
PL20000354444 |
申请日期 |
2000.09.01 |
申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
HABERMANN PAUL;BENDER RUDOLF |
分类号 |
C07K14/815;G01N33/50;A61P7/02;C07K14/21;C07K14/24;C07K14/245;C12N1/21;C12N9/02;C12N15/09;C12N15/62;C12N15/70;C12P21/02;C12Q1/37;G01N33/15 |
主分类号 |
C07K14/815 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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