摘要 |
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069 PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. |
申请人 |
GENENTECH, INC.;LEXICON PHARMACEUTICALS, INC. |
发明人 |
HORNER, ALLISON ANNE BYERS;COMBS, KATHERIN E.;DESAUVAGE, FREDERIC;FAN, LIANGFEN;FILVAROFF, ELLEN;IRVING, BRYAN;JUNUTULA, JAGATH REDDY;MASSEY, ERIN MARIE;MCLAIN, DINA REBECCA;MINZE, LAURIE JEANETTE;MONTGOMERY, CHARLES A;PAYNE, BOBBY JOE;PHILLIPS, HEIDI;RANGEL, CAROLINA;SHI, ZHENG-ZHENG;SPARKS, MARY JEAN;STALA, JOY ANNE;TOWNSEND, TERESA GAIL;VOGEL, PETER;SEVAUX, TRACY ELLEN WILLIS |