发明名称 |
IMMUNOGENIC LIVE ROTAVIRUS COMPOSITIONS WITH REDUCED RISK OF SIDE EFFECTS |
摘要 |
The present invention provides compositions for making a medicament and methods for the administration of a vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human x rhesus reassortant rotavirus compositions were made which when administered during the first 7 to about 10 days of life, provided a composition which was non-reactogenic followed by booster immunizations at 16 to 18 weeks or 14 to 20 weeks, up to 1 year of age. The immune response induced by the initial neonatal administration of the live rotavirus vaccine composition protects the infant from the reactogenicity of the composition when administered as a second vaccine dose at or after 2 months of age. Administration of the immunogenic composition also is expected to ablate or significantly diminish the increase in the excess of intussusception observed 3 to 7 days following administration of the initial dose of rotavirus vaccine at about 2 to 4 months. |
申请公布号 |
EP1251869(B1) |
申请公布日期 |
2010.03.31 |
申请号 |
EP20010905127 |
申请日期 |
2001.01.26 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
KAPIKIAN, ALBERT;CHANOCK, ROBERT;UDEM, STEPHEN;VESIKARI, TIMO |
分类号 |
A61K39/15;A61P1/12;A61P31/12 |
主分类号 |
A61K39/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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