A process for the preparation of poly-alfa-glutamic acid and derivatives thereof

摘要

The invention relates to an improved process for the preparation of poly-±-glutamic acids which comprises the polymerisation of tertiary ³-esters of ±-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-±-glutamic acid-³-ester. The process is particularly advantageous in that it allows to carefully control the molecular weight of the resulting poly-±-glutamic acid. The invention also relates to poly-±-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.