发明名称 |
TRIAZOLE-BASED AMINOGLYCOSIDE-PEPTIDE CONJUGATES AND METHODS OF USE |
摘要 |
<p>Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycoside antibiotic may exhibit antimicrobial activities against Gram-positive and/or Gram-negative strains and display significantly enhanced activity against multi-drug resistant MRSA and MRSE when compared to their unconjugated aminoglycoside antibiotic counterparts.</p> |
申请公布号 |
EP2167522(A2) |
申请公布日期 |
2010.03.31 |
申请号 |
EP20080832270 |
申请日期 |
2008.05.28 |
申请人 |
UNIVERSITY OF MANITOBA |
发明人 |
SCHWEIZER, FRANK;ZHANEL, GEORGE, G.;BERA, SMRITILEKHA |
分类号 |
C07H19/056;A61K31/7028;A61K45/00;A61P31/04;C07G3/00;C07G11/00;C07K1/06;C07K4/00;C07K5/078;C07K5/097;C07K5/117;C07K9/00 |
主分类号 |
C07H19/056 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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