发明名称 |
5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION |
摘要 |
The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: (see formula I) wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.
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申请公布号 |
CA2423631(C) |
申请公布日期 |
2010.03.30 |
申请号 |
CA20012423631 |
申请日期 |
2001.10.02 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
OKAZAKI, KOSUKE;UCHIDA, MASAHIKO;MUKAIYAMA, HARUNOBU;KOBAYASHI, HIROAKI;KAI, YUICHIRO;TAKEUCHI, HIDEKI;YOKOYAMA, KENJI;TERAO, YOSHIHIRO;HOYANO, YUJI;SHIOHARA, HIROAKI;KIKUCHI, NORIHIKO |
分类号 |
C07C311/37;A61K31/216;A61K31/4245;A61K31/426;A61K31/5375;A61P7/02;A61P9/10;C07C311/29;C07C317/32;C07D271/10;C07D277/28;C07D295/18 |
主分类号 |
C07C311/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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