| 摘要 |
Disclosed is a process for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, which is characterized by isomerizing a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative and a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative in the presence of an aluminum compound represented by the formula: Al(OR)[wherein Rrepresents a hydrocarbon group in which the carbon having an oxygen atom bound thereto is a secondary carbon]. In the process, a ketone compound may be further added, in addition to the aluminum compound.
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