| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: method involves crystallisation of iodixanol from a crude product containing approximately 75-90 wt % iodixanol, 3-10 wt % iohexol, 3-7 wt % 5-acetamido- N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodisophthalamide and trace amounts of other impurities in a solvent containing 1-methoxy-2-propanol. As a rule, the crystallisation process comprises a single step and lasts a total of 1-4 days, mainly approximately 2 days. ^ EFFECT: high output of desired product. ^ 12 cl, 1 dwg, 4 ex |
