EXTRACT OF SPARASSIS CRISPA AND ITS USE AS ANTI-INFLAMMATORY MEDICINE

摘要

PURPOSE: A composition for treating inflammatory diseases containing Sparassis crispa extract is provided. CONSTITUTION: A Sparassis crispa extract is cultivated by inoculating spawn of Sparassis crispa to Cryptomeria japonica. The Sparassis crispa contains 50.6% of GC content at ITS site of nucleic acid ribosome DNA. The extract is isolated using water, distilled water, ethanol, or their mixture solvent. The sequence of ITS site comprises a sequence of sequence number 1. The extract isolated by water has anti-oxidative activity. The anti-oxidative activity is activity of suppressing NO generation and inflammatory cytokine such as TNF-alpha, IL-6 and IL-1 beta.