发明名称 |
Crystalline form of bis [(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoicacid] calcium salt |
摘要 |
Disclosed is a crystalline hydrated from of the compound bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxyhept-6-enoic acid] calcium salt, as shown in formula I, having an X-ray powder diffraction pattern as described. Also disclosed is a process for producing the amorphous compound from the crystalline form above, the use of the crystalline form to aid isolation of the amorphous form, and the use to recover the compound from waste solutions. Also disclosed is a process for the manufacture of the crystalline form, and the use of the crystalline from for treating diseases or disorders where inhibition of HMG CoA reductase is beneficial.
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申请公布号 |
NZ545785(A) |
申请公布日期 |
2010.03.26 |
申请号 |
NZ20040545785 |
申请日期 |
2004.09.08 |
申请人 |
ASTRAZENECA UK LIMITED |
发明人 |
BOOTH, REBECCA JANE;CITTERN, PETER ANTHONY;CRABB, JEFFREY NORMAN;HORBURY, JOHN;JONES, DAVID WYN CALVERT |
分类号 |
C07D239/42;A61K31/505;A61P3/06 |
主分类号 |
C07D239/42 |
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