Stable and filterable enveloped virus formulations

摘要

Disclosed is a method for stabilizing an enveloped virus for storage in aqueous solution for six months or longer at a temperature from -4 degrees Celsius to -30 degrees Celsius, comprising preparing an aqueous solution consisting essentially of: the enveloped virus at a concentration of from 106 PFU/mL to 1012PFU/ml; and a non-reducing saccharide, wherein the saccharide is a disaccharide and is present in the solution at a concentration of from 5%(w/v) to 50%(w/v) or a monosaccharide and is present in the solution at a concentration of from 2.5% (w/v) to 25%(w/v); wherein the solution has an osmotic pressure of about 250 mOs or higher; has a pH of from 5 to 10; and contains less than 0.1% (w/v) sodium chloride.