Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament

摘要

Disclosed is a compound of formula (I), or an N-oxide, a pharmaceutically acceptable addition salt, or a stereochemically isomeric form thereof, wherein X is CH2 or O, ring C is either selected from formulas (c-1) or (c-2), wherein Y1 is S, S(=O), S(=O)2, or NR10, and R10 and R11 may together from a ring as described, or ring C is selected from (c-4) or (c-5), wherein Y2 is O or NH, and wherein the other substituents are as defined in the specification. Also disclosed is the use of the compound for treating conditions mediated through the 5-HT2 or D2 receptor, or for treating central nervous system disorders such anxiety, depression, psychosis schizophrenia, migraine, and addictive properties of drug abuse.