| 摘要 |
Disclosed is a process for the preparation of telmisartan of formula (I), or a pharmaceutically acceptable salt thereof, wherein 1H-benzimidazole-2-n-propyl-4-methyl-6-(1'-methyl benzimidazole-2'-yl) of formula (II) and methyl-4-(bromomethyl)biphenyl-2-carboxylate of formula (III) are subjected to condensation and hydrolysis in a single step followed by pH adjustment using an aqueous acid. Also disclosed is a pharmaceutically acceptable composition for administering to a patient, suffering from, or susceptible to, a disease state prevented, ameliorated or eliminated by the administration of an angiotensin II receptor antagonist, which composition comprises a therapeutically effective amount of telmisartan, or a pharmaceutically acceptable salt thereof where the telmisartan is prepared by the above process, together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
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