| 摘要 |
Provided is a method of diagnosing a susceptibility to type II diabetes in an individual, comprising analyzing in vitro the individual for a marker or haplotype within the exon 4 LD block of TCF7L2, between markers rs4074720 and rs7087006, wherein the marker or haplotype is in strong linkage disequilibrium, characterized by numerical values ofr2 greater than 0.2, with the at least one marker selected from DG10S478, rs12255372, rs7895340, rsll196205, rs7901695, rs7903146, rs12243326 and rs4506565, and, wherein the presence of the marker or haplotype is indicative of a susceptibility to type II diabetes. Further provided is a similarly based method of assessing an individual for probability of response to a TCF7L2 therapeutic agent. |
