Pyrimidine derivatives and methods of treatment related to the use thereof

摘要

The present disclosure encompasses novel substituted pyrimidine compounds of Formula (I) which act as MCH receptor antagonists, wherein Q is defined by formulae (IIa) and (IIb) and the variables L, Y and R1 are as defined in the specification. Also disclosed are pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.