发明名称 |
ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES, ADJUVANTS, AND INTIVIRAL, ANTIBACTERIAL, AND ANTICANCER AGENTS |
摘要 |
The present disclosure relates to synthetic alpha-galactosyl ceramide (a- GalCer) analogs, and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response. |
申请公布号 |
WO2010006315(A3) |
申请公布日期 |
2010.03.25 |
申请号 |
WO2009US50328 |
申请日期 |
2009.07.10 |
申请人 |
ACADEMIA SINICA;WONG, CHI-HUEY;YU, ALICE;CHANG, YA-JEN;LIN, KUN-HSIEN;CHENG, Y. S., EDMOND;JAN, JIA-TSRONG;LIN, YI-LING;HUNG, JUNG-TUNG |
发明人 |
WONG, CHI-HUEY;YU, ALICE;CHANG, YA-JEN;LIN, KUN-HSIEN;CHENG, Y. S., EDMOND;JAN, JIA-TSRONG;LIN, YI-LING;HUNG, JUNG-TUNG |
分类号 |
A61K39/39;A61K31/70;A61P31/04;A61P31/16;A61P35/00 |
主分类号 |
A61K39/39 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|