发明名称 |
Animal model exhibiting cancer, pulmonary emphysema and cardiomyopathy |
摘要 |
A transgenic mouse model for colorectal cancer, pulmonary emphysema or cardiomyopathy comprises a transgenic mouse that produces suboptimal levels of latent transforming growth factor &bgr; binding protein 4 (LTBP-4). The transgenic mouse includes a mutation resulting in homozygous disruption of both endogenous alleles of a gene encoding LTBP-4, and develops colorectal cancer, pulmonary emphysema or cardiomyopathy.
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申请公布号 |
US2010077490(A1) |
申请公布日期 |
2010.03.25 |
申请号 |
US20090321839 |
申请日期 |
2009.01.26 |
申请人 |
FRANKGEN BIOTECHNOLOGIE AG |
发明人 |
VON MELCHNER HARALD;THOREY IMGARD S.;WEMPE FRANK;STEMER-KOCK ANJA;KESKI-OJA JORMA |
分类号 |
G01N33/574;A01K67/027;C07K14/78;C12N5/07;C12N15/12;C12N15/85;G01N33/50 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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