发明名称 |
MOLECULES THAT SELECTIVELY HOME TO VASCULATURE OF PREMALIGNANT OR MALIGNANT LESIONS OF THE PANCREAS AND OTHER ORGANS |
摘要 |
The invention provides a conjugate that includes a therapeutic moiety linked to a peptide or peptidomimetic that selectively homes to vasculature of premalignant pancreas. The peptide or peptidomimetic contains at least 5 contiguous amino acids of an amino acid sequence selected from CRSRKG (SEQ ID NO:9) and CEYQLDVE (SEQ ID NO:34), or a conservative variant or peptidomimetic thereof. The invention additionally provides a conjugate containing a therapeutic moiety linked to a peptide or peptidomimetic that selectively homes to pancreatic tumor cells and pancreatic tumor vasculature, the peptide or peptidomimetic comprising at least 5 contiguous amino acids of an amino acid sequence selected from CKAAKNK (SEQ ID NO:15), CKGAKAR (SEQ ID NO:19), and VGVGEWSV (SEQ ID NO:35), or a conservative variant or peptidomimetic thereof.
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申请公布号 |
US2010076175(A1) |
申请公布日期 |
2010.03.25 |
申请号 |
US20090559305 |
申请日期 |
2009.09.14 |
申请人 |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
HANAHAN DOUGLAS;RUOSLAHTI ERKKI;JOYCE JOHANNA A.;LAAKKONEN PIRJO |
分类号 |
C07K7/06;A61K;A61K38/00;A61K47/48;A61K49/00;C07K5/00;C07K14/47 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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