| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a compound having raf kinase inhibiting activity and a treatment of cancerous cell growth mediated by the compound. <P>SOLUTION: The compounds are ureido-thiophene-carboxylic acid methyl esters represented by the formula, such as 5-bromomethyl-3-(3-p-tolylureido)-thiophene-2-carboxylic acid methyl ester, 5-tert-butyl-3-[3-(5-trifluoromethyl-[1, 3, 4]-thiadiazol-2-yl)ureido]-thiophene-2-carboxylic acid methyl ester, or the like. <P>COPYRIGHT: (C)2010,JPO&INPIT</p> |
