摘要 |
Modified glucagon peptides are disclosed having improved solubility and/or half-life while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.
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申请人 |
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION;DIMARCHI, RICHARD, D.;SMILEY, DAVID, L.;DIMARCHI, MARIA;CHABENNE, JOSEPH;DAY, JONATHAN |
发明人 |
DIMARCHI, RICHARD, D.;SMILEY, DAVID, L.;DIMARCHI, MARIA;CHABENNE, JOSEPH;DAY, JONATHAN |