The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.
申请公布号
AU2009217425(A1)
申请公布日期
2010.03.25
申请号
AU20090217425
申请日期
2009.03.06
申请人
GLAXOSMITHKLINE BIOLOGICALS S.A.;UTRECHT UNIVERSITY
发明人
JAN POOLMAN;JOHANNES PETRUS MARIA TOMMASSEN;MARTINE PETRONELLO BOS;MICHIEL STORK;VINCENT WEYNANTS