COMPOSITION FOR PREVENTING OR TREATING THE HEART FAILURE

摘要

PURPOSE: A composition for preventing or treating heart failure is provided to change calcium sensitivity in cardiomyocytes using PKCζ(protein kinase C ζ) inhibitor. CONSTITUTION: A composition for preventing or treating heart failure contains PKCζ(protein kinase C ζ) inhibitor as an active ingredient. The PKCζ inhibitor is a compound of chemical formula I. In chemical formula I, R1 and R2 are independently alkoxycarbonyl group, substituted alkoxycarbonyl group, aryl group or substituted aryl group. At least one of R1 and R2 is alkoxycarbonyl group or substituted alkoxy carbonyl grouip.