| 摘要 |
PURPOSE: A cosmetic composition is provided to enhance collagen synthesis in fibroblasts using medium for culturing stem cells derived from mammal. CONSTITUTION: A cosmetic composition contains a medium for culturing stem cells derived from mammal. The stem cells are derived from adipose, amnion, umbilical cord blood or bone marrow of mammal. An adipose-derived stem cell is an self-derived stem cell. The medium contains cytokine isolated from the stem cells. The cytokine is selected from 'MCP-2(Monocyte chemotactic protein-2), MCP-4(Monocyte chemotactic protein-4), MDC(Macrophage Derived Chemokine), NAP-2(Neutrophil-activating peptide-2), ICAM-1(Intercellulat adhesion molecule-1/CD54), MIP-1α (Macrophage inflammatory protein 1 alpha), MIP-1β(Macrophage inflammatory protein 1 beta), sTNF-RII (soluble tumour necrosis factor receptor II), sTNFRI(soluble tumour necrosis factor receptor I), TIMP-1 (Tissue inhibitor of metalloproteinase 1), TIMP-2 (Tissue inhibitor of metalloproteinase 2), uPAR (urokinase type plasminogen activator receptor), CD14 (LPS-R lipopolysaccharide receptor), CXCL-16 (Chemokine(C-X-C motif) ligand 16), MMP-9(Metrix metallopeptidase 9), PDGF-AA (Platelet-derived growth factor AA) and TGF β2 (Transforming growth factor-beta2).
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