NUCLEIC ACID DRUG FOR TREATING ALLERGIC DISEASE

摘要

Provided is a double-stranded (ds)RNA capable of inhibiting the expression of STAT6, which participates in allergic diseases via Th2 type cytokine, by the RNA interference. Also provided is a medicinal composition for preventing or treating an allergic disease which contains the preceding dsRNA. A double-stranded RNA (dsRNA) molecule targeting mRNA in STAT6 gene which satisfies the following requirement (a) or (b): (a) one strand is a sense strand identical with a sequence having 15 to 50 consecutive bases in the STAT6 gene sequence represented by SEQ ID NO:1 or 3, while the other strand is an antisense strand containing a base sequence being complementary to the base sequence of the preceding sense strand; and (b) one strand is a sense strand comprising a sequence derived from a sequence having 15 to 50 consecutive bases in the STAT6 gene sequence represented by SEQ ID NO:1 or 3 by deletion, substitution or addition of one to several bases and being hybridizable with STAT6 gene, while the other strand is an antisense strand containing a base sequence being complementary to the base sequence of the preceding sense strand.