GAS EMPOWERED EXPANDABLE DRUG DELIVERY SYSTEMS

摘要

An expandable drug delivery system comprising of one or more actives, force generating components, optionally containing one or more absorption modifiers and optionally containing one or more bioadhesive polymers. The active ingredient is entrapped into the nano/microsized particles of a mucoadhesive polymer matrix. The single unit dosage form is optionally coated with a degradable separating and/or enteric coating layer. An expandable drug delivery system for oral delivery consisting of a protein or peptide drug(s), force-generating components, with/with out absorption modifiers, wherein the composition is formulated to increase the residence time drug containing sub-units of the delivery system in the GIT, optionally coated with enteric polymers. An expandable drug delivery system consisting of a peptide drug, expandable polymer matrix, expanding force-generating component, which delivers drug to the absorbing membrane after a lag time followed by a burst release or sustained release.