| 发明名称 |
MARKERS ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF GLATIRAMER ACETATE |
| 摘要 |
The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPP1 and IL-12RB2. |
| 申请公布号 |
EP1891233(A4) |
申请公布日期 |
2010.03.24 |
| 申请号 |
EP20060758673 |
申请日期 |
2006.04.24 |
| 申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD.;TEVA PHARMACEUTICAL INDUSTRIES, LTD.;RAPPAPORT FACULTY OF MEDICINE AND RESEARCH INSTITUTE |
发明人 |
LANCET, DORON;BECKMANN, JACQUES;AVIDAN, NILI;BEN-ASHER, EDNA;GOLDSTAUB, DAN;HAYARDENY, LIAT;GROSSMAN, IRIS;MILLER, ARIEL;SINGER, CLARA |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
