发明名称 MALONAMIDE DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY
摘要 The present invention relates to compounds of the formula (I). The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are inhibitors of the blood clotting enzymes, especially factor VIla and can in general be applied in conditions in which an undesired activity of factor VIla is present or for the cure or prevention of which an inhibition of factor VIla is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
申请公布号 KR20100031732(A) 申请公布日期 2010.03.24
申请号 KR20107000391 申请日期 2008.06.26
申请人 SANOFI-AVENTIS 发明人 STEINHAGEN HENNING;SZILLAT HAUKE;FOLLMANN MARKUS;KIRSCH REINHARD;WEHNER VOLKMAR;MATTER HANS;LORENZ MARTIN;NEUENSCHWANDER KENT W.;SCOTESE ANTHONY C.
分类号 C07D213/34;A61K31/44;C07D309/08;C07D409/12 主分类号 C07D213/34
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