发明名称 |
MAGNETIC NANOPARTICLES FOR TRANSFERRING NUCLEIC ACIDS INTO CELLS AND METHOD FOR PREPARING THE SAME |
摘要 |
PURPOSE: A magnetic nano particle for a nucleic acid cell transfer and a producing method thereof are provided to perfectly coat a metal oxide magnetic particle with a silane including an epoxy-based functional group. CONSTITUTION: A producing method of a magnetic nano particle for a nucleic acid cell transfer comprises the following steps: (a)thermally decomposing a mixture of carbonyl metal and a stabilizer after removing oxygen; forming a metal magnetic nano particle; (b)forming a metal oxide magnetic nano particle by reacting the metal magnetic nano particle with oxygen; (c)forming a metal oxide magnetic nano particle coated with functional silane by reacting the metal oxide magnetic nano particle with a functional silane compound and ultra-pure water; and (d)producing a magnetic nano particle for the cell transfer by reacting the metal oxide magnetic nano particle coated with functional silane with a compound for the cell transfer.
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申请公布号 |
KR20100031262(A) |
申请公布日期 |
2010.03.22 |
申请号 |
KR20080090268 |
申请日期 |
2008.09.12 |
申请人 |
BIONEER CORPORATION |
发明人 |
KIM, JAE HA;PARK, JONG GWANG;KIM, MI NA;PARK, HAN OH |
分类号 |
B82B3/00;A61K48/00 |
主分类号 |
B82B3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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