<p>Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.</p>
申请公布号
WO2010029500(A1)
申请公布日期
2010.03.18
申请号
WO2009IB53921
申请日期
2009.09.08
申请人
KONINKLIJKE PHILIPS ELECTRONICS N.V.;GRUELL, HOLGER;DE VRIES, ANKE;LANGEREIS, SANDER;LUB, JOHAN;AUSSEMS-CUSTERS, ERICA, M., G.
发明人
GRUELL, HOLGER;DE VRIES, ANKE;LANGEREIS, SANDER;LUB, JOHAN;AUSSEMS-CUSTERS, ERICA, M., G.