发明名称 |
SUBSTITUTED LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION |
摘要 |
This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
|
申请公布号 |
US2010069373(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20090615799 |
申请日期 |
2009.11.10 |
申请人 |
BRISTOL-MYERS SQUIBB PHARMA COMPANY |
发明人 |
HAN QI;LIU HONG;OLSON RICHARD E.;YANG MICHAEL G. |
分类号 |
A61K31/5513;A61K31/55;A61P25/28;C07D223/12;C07D223/18;C07D243/12;C07D243/24;C07D401/04 |
主分类号 |
A61K31/5513 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|