发明名称 |
METHOD FOR PREPARING CLOPIDOGREL AND ITS DERIVATIVES |
摘要 |
The present invention relates to a method for preparing Clopidogrel and its derivatives. More particularly, the present invention is a method for preparation of (S)-2-Clopidogrel and its derivatives, which are active inhibitors of platelet aggregation, from an optically active (S)-2-chlorophenylglycine alkyl ester through hydrolysis of racemic 2-chlorophenylglycine alkyl esters using an enzyme. The present invention employs a simple procedure to prepare Clopidogrel and its derivatives. Because no chiral resolving agents are used except for a small amount of enzyme, the cost of preparation can be reduced. In addition, the present invention is suitable for synthesizing highly optical-active Clopidogrel and its derivatives on a large scale by using optically active (S)-2-chlorophenylglycine alkyl ester obtained in high yield as an intermediate, and is also environmentally friendly since no highly toxic reagents are employed. |
申请公布号 |
WO2009151256(A3) |
申请公布日期 |
2010.03.18 |
申请号 |
WO2009KR03083 |
申请日期 |
2009.06.09 |
申请人 |
ENZYTECH LTD.;HWANG, SOON OOK;KIM, KWANG SOO;KIM, YOUNG JIN;JUNG, CHEON OH |
发明人 |
HWANG, SOON OOK;KIM, KWANG SOO;KIM, YOUNG JIN;JUNG, CHEON OH |
分类号 |
C07D495/04 |
主分类号 |
C07D495/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|