NOVEL SHRNA GENE THERAPY FOR TREATMENT OF ISCHEMIC HEART DISEASE

摘要

Short hairpin RNA (shRNA) interference therapy targeting hypoxia inducible factor- lot (HIF-1 a) prolyl-4-hydroxylase protein (HIF-PHD2) is used for treatment of myocardial ischemia. This treatment can be followed noninvasively by molecular imaging. Provided are compositions comprising novel vectors encoding shRNA targeting the HIF-1a and asparaginyl hydroxylase genes. The vectors encoding shRNA are also useful for the treatment of cardiac diseases, peripheral vascular diseases and decubitis ulcers.