发明名称 |
NURR1 INTERACTING PROTEIN (NUIP) |
摘要 |
Provided herein are methods of promoting the activity of Nurr1 in a cell comprising contacting the cell with NuIP or an analog or fragment thereof. Also provided are methods of treating or preventing a condition associated with reduced dopaminergic function in a subject, comprising administering to the subject NuIP or an analog or fragment thereof. Methods of inhibiting the activity of Nurr1 in a cell comprising contacting the cell with a NuIP inhibitor are provided. Methods of screening for agents that modulate the interaction of Nurr1 and NuIP are also provided. |
申请公布号 |
WO2010030653(A2) |
申请公布日期 |
2010.03.18 |
申请号 |
WO2009US56346 |
申请日期 |
2009.09.09 |
申请人 |
UNIVERSITY OF ROCHESTER;FEDEROFF, HOWARD, J. |
发明人 |
FEDEROFF, HOWARD, J. |
分类号 |
C12N15/63;A61K38/17;A61K39/395;A61P25/28;C07K14/47;C07K16/18 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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