摘要 |
<p>The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1), a pharmaceutical composition comprising the compound or a salt, hydrate or solvate thereof as an active ingredient, a method for the prevention or the treatment of a SSAO/VAP-1 related disease, said diseases including acute or chronic inflammatory diseases, diseases related to carbohydrate metabolism, diabetes-associated complications, diabetic retinopathy and macular oedema, diseases related to adipocyte or smooth muscle dysfunctions, neurodegenerative diseases and vascular diseases.</p> |
申请人 |
SEMMELWEIS EGYETEM;MATYUS, PETER;MAGYAR, KALMAN;PIHLAVISTA, MARJO;GYIRES, KLARA;HAIDER, NORBERT;WANG, YINGHUA;WODA, PATRICK;DUNKEL, PETRA;TOTH-SARUDY, EVA;TUROS, GYOERGY |
发明人 |
MATYUS, PETER;MAGYAR, KALMAN;PIHLAVISTA, MARJO;GYIRES, KLARA;HAIDER, NORBERT;WANG, YINGHUA;WODA, PATRICK;DUNKEL, PETRA;TOTH-SARUDY, EVA;TUROS, GYOERGY |