发明名称 |
METHODS FOR TREATING AUTOIMMUNE AND CHRONIC INFLAMMATORY CONDITIONS USING ANTAGONISTS OF CD30 OR CD30L |
摘要 |
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of treating conditions resistant to treatment with TNFα inhibitors by administering agents that inhibit signal transduction by CD30 or IL-1. Included also are treatments involving concurrently administering agents that block the CD30/CD30L interaction and agents that antagonize the IL-4/IL-4R interaction. Additionally provided is an animal model for screening candidate agents for their efficacy in treating conditions that are resistant to treatment with TNFα inhibitors.
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申请公布号 |
US2010071079(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20090615619 |
申请日期 |
2009.11.10 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
MOHLER KENDALL M.;BARONE DAUPHINE S.;PESCHON JACQUES J.;KENNEDY MARY K.;PLUENNEKE JOHN D. |
分类号 |
A01K67/027;A61K49/00;A61K38/00;A61K38/16;A61K39/395;A61K45/00;A61K45/06;A61P17/02;A61P19/02;A61P25/00;A61P37/00;A61P37/06;C07K16/28;C12N15/09;G01N33/15;G01N33/48;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
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主权项 |
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地址 |
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