发明名称 |
METHODS FOR PRODUCING EMBRYONIC STEM CELLS FROM PARTHENOGENETIC EMBRYOS |
摘要 |
Means for producing embryonic stem (pES) cells which have a heterozygous genome that is matched to an individual donor are provided. In one embodiment, a means for the generation and isolation of parthenogenetic embryonic stem (pES) cells which have regions of heterozygosity that are fully matched to the oocyte donor at the MHC loci (e.g. (h-)p(MI)ES cells is provided. This is in contrast to the traditional methods of parthenogenesis that generate parthenogenetic embryonic stem (pES) cells having a substantially homozygous haploidentical set of chromosomes that are homozygous at the MHC loci.
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申请公布号 |
US2010069251(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20070440964 |
申请日期 |
2007.09.13 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
KIM KITAI;DALEY GEORGE |
分类号 |
C40B30/00;C12N5/02;C12N5/0735;C12Q1/68;C40B40/02 |
主分类号 |
C40B30/00 |
代理机构 |
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代理人 |
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地址 |
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