发明名称 |
TREATMENT OF ACUTE MYOCARDIAL INFARCTION (AMI) USING ENCAPSULATED CELLS ENCODING AND SECRETING GLP-1 PEPTIDES OR ANALOGS THEREOF |
摘要 |
<p>The present application refers to the use of cells, e.g. mesenchymal stem cells or mesenchymal stromal cells, or any further suitable cell, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, for the treatment of acute myocardial infarction (AMI or Ml), wherein the cells, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, are encapsulated in a (spherical) microcapsule to prevent a response of the immune system of the patient to be treated. The present application also refers to the use of these (spherical) microcapsule(s) or of a pharmaceutical composition containing these cells or (spherical) microcapsule(s) for the treatment of acute myocardial infarction (AMI or Ml).</p> |
申请公布号 |
WO2010028846(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
WO2009EP06620 |
申请日期 |
2009.09.11 |
申请人 |
BIOCOMPATIBLES UK LTD.;WALLRAPP, CHRISTINE;LEWIS, ANDREW LENNHARD;STRATFORD, PETER WILLIAM;THOENES, ERIC |
发明人 |
WALLRAPP, CHRISTINE;LEWIS, ANDREW LENNHARD;STRATFORD, PETER WILLIAM;THOENES, ERIC |
分类号 |
A61K9/50;A61P9/00;C12N5/00 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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