发明名称 |
CLEAN GENOME BACTOFECTION |
摘要 |
Methods for introducing and expressing genes in animal cells are provided comprising infecting the animal cells with live invasive reduced-genome bacteria comprising a eukaryotic expression cassette comprising said gene. Also provided are methods for producing a pluripotent stem (iPS) cell from a mammalian somatic cell comprising infecting the somatic cell with live invasive reduced-genome bacteria comprising one or more eukaryotic expression cassettes comprising at least a gene encoding the transcription factor Oct3/4 and a gene encoding a member of the SRY- related HMG-box (Sox) transcription factor family.
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申请公布号 |
CA2736877(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
CA20092736877 |
申请日期 |
2009.09.14 |
申请人 |
SCARAB GENOMICS, LLC |
发明人 |
BLATTNER, FREDERICK R.;BURLAND, VAL;LANDRY, CHARLES;SHI, NIAN-QING;STAHL, BUFFY |
分类号 |
C12N15/85;C12N15/70;C12N15/87 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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地址 |
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