发明名称 |
COMPOSITIONS AND TREATMENTS COMPRISING 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS AND NITRIC OXIDE MODULATORS |
摘要 |
Disclosed herein are compositions and compounds that combine an inhibitor of 5-lipoxygenase activating protein (FLAP) and a modulator of NO levels in a mammal. The NO modulator can be an agent that induces the production of NO in a mammal, or can be an agent that itself produces NO in the mammal. Further disclosed herein are strategies for synthesizing such compounds, and methods for testing whether the combination compounds and compositions provide a desired benefit. Also disclosed herein are pharmaceutical compositions and formulations that combine a FLAP inhibitor and an NO modulator. Further described herein are methods for using such compositions and compounds for the treatment of diseases, conditions, and disorders in a mammal, including a human. Such treatment methods include the separate administration of a FLAP inhibitor and a NO modulator to the mammal, and the simultaneous administration of a FLAP inhibitor and a NO modulator to the mammal.
|
申请公布号 |
US2010068301(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20070517166 |
申请日期 |
2007.11.30 |
申请人 |
HUTCHINSON JOHN H;HADDACH MUSTAPHA;MORAN MARK;EVANS JILLIAN;STOCK NICHOLAS SIMON;ROPPE JEFFREY ROGER |
发明人 |
HUTCHINSON JOHN H.;HADDACH MUSTAPHA;MORAN MARK;EVANS JILLIAN;STOCK NICHOLAS SIMON;ROPPE JEFFREY ROGER |
分类号 |
A61K31/4709;A61K31/04;A61K31/195;A61K31/34;A61K31/404;A61K31/7076;A61K33/26;A61K38/08;A61P9/12;C07D401/12 |
主分类号 |
A61K31/4709 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|