发明名称 |
METHOD FOR THE SEPARATION OF S-(-)-AMLODIPINE FROM RACEMIC AMLODIPINE |
摘要 |
Disclosed is a method for the separation of S-(−)-amlodipine from a racemic amlodipine. Featuring the use of inexpensive L-tartaric acid as an optical resolution agent and DMAC as a solvent, the separation method allows the resolution of S-(−)-amlodipine from racemic amlodipine at high yield and to a satisfactory enantiomeric excess and thus is economically favorable and applicable to the mass production of the optical isomer.
|
申请公布号 |
US2010069445(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20070447306 |
申请日期 |
2007.10.26 |
申请人 |
CJ CHEILJEDANG CORPORATION |
发明人 |
SONG SEOG BEOM;CHO IL HWAN;YOUN YONG SIK;LIM DONG KWON |
分类号 |
A61K31/44;C07D213/80 |
主分类号 |
A61K31/44 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|