COUPLING AGENTS FOR THE SYNTHESIS OF POLYPEPTIDES AND POLYNUCLEOTIDES

摘要

Novel coupling agents containing a unique leaving group moiety, which can be used beneficially and safely as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Also disclosed are processes of preparing such coupling agents and their use in the preparation of polypeptides and/or polynucleotides.