NOVEL PEPTIDE FOR AUGMENTING BRAIN-DERIVED NEUTROTROPHIC FACTOR (BDNF) PROTEIN EXPRESSION IN HIPPOCAMPAL NEURONS, HIPPOCAMPAL TISSUE AND CEREBRAL-CORTEX TISSUE

摘要

The present invention relates to a novel peptide for augmenting brain-derived neutrotrophic factor (BDNF) protein expression. More specifically, the present invention provides a novel peptide which can be used to prevent or treat neurological disorders such as Alzheimer's disease, Parkinson's disease, depression, stroke, Huntington's chorea, ischaemic disorders of the cerebrum, degenerative neurological disorders or diabetic neural disorders, by augmenting BDNF mRNA and protein expression in hippocampal and cerebral cortical tissue. A Methionine-Valine-Glycine (MVG) peptide comprising three different amino acids of the present invention augmented BDNF mRNA and protein expression in hippocampal neurons, hippocampal tissue and cerebral-cortex tissue; BDNF being an important functional substance in learning and memory, dopamine neuron protection and depression prevention.