<p>Disclosed in certain embodiments is a method of preparing a Type 1 interferon antagonist comprising modifying a Type 1 interferon at the site of interaction with the interferon receptor subunit IFNAR-1 such that the binding affinity of the interferon to the IFNAR-1 subunit is reduced as compared to the native interferon, and corresponding compositions and methods of treatment thereof.</p>
申请公布号
WO2010030671(A1)
申请公布日期
2010.03.18
申请号
WO2009US56366
申请日期
2009.09.09
申请人
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;YEDA RESEARCH & DEVELOPMENT CO. LTD.;LANGER, JEROME;SCHREIBER, GIDEON