Benzothiazepine derivatives as ryanodine receptor (RYR2) inhibitors and their use in the treatment of cardiac diseases
摘要
<p>The present application relates to benzothiazepine S36 and its oxidized derivatives tor use in limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject having a cardiac condition or in treating or preventing a cardiac condition in a subject.</p>
申请公布号
EP2163248(A1)
申请公布日期
2010.03.17
申请号
EP20090013476
申请日期
2005.03.22
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人
MARKS, ANDREW R.;LANDRY, DONALD W.;DENG, SHIXIAN;CHENG, ZHEN ZHUANG
