发明名称 |
AN IMPROVED PROCESS FOR THE PREPARATION OF ERLOTINIB HYDROCHLORIDE |
摘要 |
<p>The present invention provides an improved and commercially viable process for preparation of erlotinib substantially free of N-methoxyethyl impurity, namely N-[(3-ethynylphenyl)-(2-methoxyethyl)]-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, and its pharmaceutically acceptable acid addition salts thereof in high purity and in high yield. According to the present invention, erlotinib or a pharmaceutically acceptable acid addition salt of erlotinib substantially free of N-methoxyethyl impurity is prepared by isolating erlotinib or a pharmaceutically acceptable salt of erlotinib from a solvent medium comprising dimethyl sulfoxide and an alcoholic solvent.</p> |
申请公布号 |
EP2162444(A2) |
申请公布日期 |
2010.03.17 |
申请号 |
EP20070827518 |
申请日期 |
2007.07.11 |
申请人 |
HETERO DRUGS LIMITED |
发明人 |
PARTHASARADHI REDDY, BANDI;RATHNAKAR REDDY, KURA;RAJI REDDY, RAPOLU;MURALIDHARA REDDY, DASARI;SRINIVASA RAO, THUNGATHURTHY |
分类号 |
C07D239/94 |
主分类号 |
C07D239/94 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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